Derailed is a 2002 American vigilante action film directed by Bob Misiorowski. It stars Jean-Claude Van Damme, Tomas Arana, Laura Harring, Jessica Bowman, and Van Damme's real life son Kris Van Varenberg. In the story, a secret agent (Van Damme) must escort a thief (Harring)—and the bioweapon she has stolen—from Slovakia to Germany, but the agent's unsuspecting family and a dangerous criminal (Arana) end up on the same train as them.

In the United States, Derailed premiered on home video on October 12, 2002, although it was given a theatrical release in some international markets. The film has received extremely negative reviews, and is widely held as a low point in the actor's career.