Derailed is a 2002 American-Bulgarian action film directed by Bob Misiorowski, and starring Jean-Claude Van Damme, Tomas Arana and Laura Harring. Van Damme's son Kristopher van Varenberg also appears as his fictional son. In the story, a secret agent (Van Damme) must escort a thief (Harring)—and the bioweapon she has stolen—from Slovakia to Germany, but the agent's unsuspecting family and a dangerous criminal (Arana) end up on the same train as them.

In the United States, Derailed premiered on home video on October 12, 2002, although it was given a theatrical release in some international markets. The film has received universally negative reviews, and is widely held as a low point in the actor's career.