Mouse Hunt is a 1997 American slapstick black comedy film written by Adam Rifkin and directed by Gore Verbinski in his feature film directorial debut. It stars Nathan Lane, Lee Evans, Maury Chaykin, and Christopher Walken. The film follows two Laurel and Hardy-like brothers in their struggle against one small but crafty house mouse for possession of a mansion which was willed to them by their father. While the film is set in the late 20th century, styles range humorously from the 1940s to the 1990s.

It was the first family film to be released by DreamWorks Pictures, who released it in the United States on December 19, 1997, to mixed reviews, but was a commercial success, earning $125.4 million on the box office against a budget of $38 million. It has also grown a cult following in recent years.

Mouse Hunt features one of William Hickey's final roles. The film was dedicated to his memory.