The Ladykillers is a 2004 American black comedy crime thriller film written, directed, produced and edited by Joel and Ethan Coen. The Coens' screenplay was based on the 1955 British Ealing comedy film of the same name, which was written by William Rose. The Coens produced the remake with Tom Jacobson, Barry Sonnenfeld, and Barry Josephson. It stars Tom Hanks, Irma P. Hall, Marlon Wayans, J. K. Simmons, Tzi Ma and Ryan Hurst, and marks the only time the Coens have worked with Tom Hanks so far and the first remake by the Coens. This was the first film in which Joel and Ethan Coen share both producing and directing credits; previously Joel had always been credited as director and Ethan as producer.

The Ladykillers received mixed reviews and grossed $76 million worldwide. Many critics consider it one of the Coen brothers' weaker efforts, negatively comparing it to the British classic.