Drugstore Cowboy is a 1989 American crime drama film directed by the American filmmaker Gus Van Sant. Written by Van Sant and Daniel Yost and based on an autobiographical novel by James Fogle, the film stars Matt Dillon, Kelly Lynch, Heather Graham and William S. Burroughs. It was Van Sant's second film as director.

At the time the film was made, the source novel by Fogle was unpublished. It was later published in 1990, by which time Fogle had been released from prison. Fogle, like the characters in his story, was a long-time drug user and dealer.

The film was theatrically released in the United States on October 6, 1989, and received acclaim from critics.