Gabriel Knight: Sins of the Fathers is a 1993 point-and-click adventure game, created by Jane Jensen, developed and published by Sierra On-Line, and released for MS-DOS, Macintosh, and Windows on December 17, 1993. The game's story, featuring the voices of Tim Curry, Leah Remini, and Mark Hamill in the CD-ROM version, focuses on Gabriel Knight, a struggling novelist, whose decision to use a spate of recent murders around New Orleans as material for a new novel, leads him into a world of voodoo magic and the truth about his family's past as supernatural fighters.

Although the game was not a commercial success, it received favourable reviews from critics for its story and voice cast, along with its graphical presentation. The game later spawned a series, with a sequel, The Beast Within: A Gabriel Knight Mystery, released in 1995; the game also received a novel adaptation by Jensen, published in 1997.

A remake of the game to mark its 20th anniversary, Gabriel Knight: Sins of the Fathers 20th Anniversary Edition, was released in 2014 for Windows, Mac, iPad, and Android, featuring a remastering of the graphics and music, along with a new voice cast and minor changes to the arrangement of story events