Garfield: A Tail of Two Kitties (released in some countries as Garfield 2) is a 2006 adventure comedy film directed by Tim Hill and written by Joel Cohen and Alec Sokolow. It is the sequel to Garfield: The Movie (2004), and stars Breckin Meyer, Jennifer Love Hewitt, and Bill Murray reprising their respective roles as Jon Arbuckle, Dr. Liz Wilson, and the voice of Garfield. New cast members include Billy Connolly, Ian Abercrombie, Roger Rees, Lucy Davis and Oliver Muirhead in live-action roles and Tim Curry, Bob Hoskins, Rhys Ifans, Vinnie Jones, Joe Pasquale, Richard E. Grant, and Jane Leeves as the voices of the film's new animal characters. In the film, Garfield, Odie, Liz and Jon travel to the United Kingdom, where Prince, another cat that looks exactly like Garfield, is ruling over a castle after the death of his owner. His reign is soon jeopardized by an evil aristocrat, who plans to remodel the castle into condominiums, destroy the estate, and get rid of Prince. The story is loosely inspired by Mark Twain's novel The Prince and the Pauper, while its title is a parody of Charles Dickens' A Tale of Two Cities.

Garfield: A Tail of Two Kitties was released by 20th Century Fox in the United States and United Kingdom on June 16, 2006. Like its predecessor, the film received generally negative reviews from critics. A tie-in video game was developed by The Game Factory.