Misis Mo, Misis Ko (English: Your Wife, My Wife) is a 1988 Philippine melodrama film directed by Carlos Siguion-Reyna in his feature film directorial debut from a story and screenplay written by his wife Bibeth Orteza, with Amado Lacuesta Jr. as script consultant. Starring Edu Manzano, Dina Bonnevie, Jackie Lou Blanco, and Ricky Davao, the film revolves around the infidelities of two married couples.

Co-produced by Armida Siguion-Reyna, she tested producing a film with Viva Films, under the helm of its founder and executive producer Vic del Rosario. The film was theatrically released on 10 February 1988 to critical and box office success. Armida's successful attempt led to the establishment of Reyna Films, with their first film released three years later.