Silkwood is a 1983 American biographical drama film directed by Mike Nichols, and starring Meryl Streep, Kurt Russell, and Cher. The screenplay by Nora Ephron and Alice Arlen was adapted from the book Who Killed Karen Silkwood? by Rolling Stone writer and activist Howard Kohn, which detailed the life of Karen Silkwood, a nuclear whistle-blower and a labor union activist who investigated alleged wrongdoing at the Kerr-McGee plutonium plant where she worked. In real life, her inconclusive death in a car crash gave rise to a 1979 lawsuit, Silkwood v. Kerr-McGee, led by attorney Gerry Spence. The jury rendered its verdict of $10 million in damages to be paid to the Silkwood estate (her children), the largest amount in damages ever awarded for that kind of case at the time. The Silkwood estate eventually settled for $1.3 million.

The development of Silkwood spanned nine years, with the project originating with Warner Bros., who intended to cast Jane Fonda as Silkwood. Warner Bros. ultimately abandoned the project after producer Buzz Hirsch was subpoenaed by an Oklahoma City judge to disclose all of the film's research materials, an effort that was overruled by a 10th Circuit Court of Appeals in Denver. The project was later acquired by ABC Motion Pictures, with Nichols directing and Streep cast in the title role. Silkwood was shot largely in New Mexico and Texas on a budget of $10 million. Factual accuracy was maintained throughout the script. One scene in particular involved Silkwood activating a radiation alarm at the plant; Silkwood herself had forty times the legal limit of radioactive contamination in her system.

Streep had just finished filming Sophie's Choice (1982) when production began. The film marked a departure for some of its stars: it is noted for being one of the first serious works of Cher, who had been previously known mostly for her singing, and for Russell, who was at the time widely known for his work in the action genre.

The film received positive reviews and was a box office success, with particular attention focused on Nichols' direction and Streep's performance. At the 56th Academy Awards, Silkwood received five nominations in total, including Streep for Best Actress, Cher for Best Supporting Actress and Nichols for Best Director.