La pequeña señora de Pérez (Spanish for "Little Mrs. Pérez") is a 1944 Argentine comedy film of the classical era of Argentine cinema, directed by Carlos Hugo Christensen and starring Mirtha Legrand and Juan Carlos Thorry. It tells the story of Julieta Ayala, a 17-year-old girl who drops out of high school to marry young doctor Carlos Pérez, only to soon re-enroll undercover after finding married life boring.

At the 1945 Argentine Film Critics Association Awards, Legrand won the Silver Condor Award for Best Actress for her performance in the film.

A sequel, titled La señora de Pérez se divorcia, was released in 1945.