Safo, historia de una pasión is a 1943 Argentine erotic melodrama film directed by Carlos Hugo Christensen and starring Mecha Ortiz and Roberto Escalada, one of the most famous titles from the Golden Age of Argentine cinema. The film is based on the 1884 Alphonse Daudet novel Sappho. At the 1944 Argentine Film Critics Association Awards, Ortiz won the Silver Condor Award for Best Actress for her performance as Selva in the film.

In a survey of the 100 greatest films of Argentine cinema carried out by the Museo del Cine Pablo Ducrós Hicken in 2000, the film reached the 43rd position.