Big Business is a 1988 American comedy film starring Bette Midler and Lily Tomlin, each playing two roles, as sets of identical twins mismatched at birth. The nature versus nurture farce adapts The Comedy of Errors, but with female siblings in contemporary society: one of each twin being reared in a wealthy urban setting, while the others grew up in a poor rural environment.

Produced by Touchstone Pictures, the film co-stars Fred Ward, Edward Herrmann, Joe Grifasi, and Seth Green, as well as siblings Michael Gross and Mary Gross. Directed by Jim Abrahams, critical reaction to the film as a whole was generally lukewarm. Both Midler and Tomlin were nominated for the American Comedy Award for Funniest Actress in a Motion Picture for their performances with Midler winning.