What's the Worst That Could Happen? is a 2001 American crime comedy film directed by Sam Weisman and starring Martin Lawrence and Danny DeVito. Loosely based on a book by Donald E. Westlake, the film follows the misadventures of a skilled thief and a wealthy businessman facing financial trouble. The film did not meet expectations and performed poorly commercially.

Upon its release in June 2001, What's the Worst That Could Happen? earned $38.4 million worldwide against its $60 million budget. Critics widely panned the film, with a 10% rating on Rotten Tomatoes. The film was criticized for its uninspiring script and lack of funny gags, and for underutilizing its cast. Reviewers like Roger Ebert and Lisa Schwarzbaum pointed out flaws in the film's character development, plot, and the mismatched acting styles of its stars.