The Powerpuff Girls Movie is a 2002 American animated superhero film based on the Cartoon Network animated television series The Powerpuff Girls. It was co-written and directed by series' creator Craig McCracken (in his feature-length directorial debut), co-written by Charlie Bean, Lauren Faust, Paul Rudish, and Don Shank, and stars the regular television cast of Catherine Cavadini, Tara Strong, E. G. Daily, Roger L. Jackson, Tom Kane, Tom Kenny, Jennifer Hale, and Jennifer Martin. The film serves as a prequel to the series, and tells the origin story of how the Powerpuff Girls were created and came to be the defenders of Townsville and how Mojo Jojo became a supervillain.

Produced by Cartoon Network Studios as its first theatrical film, and the first theatrical film to be based on a Cartoon Network series, The Powerpuff Girls Movie was released in theaters on July 3, 2002, by Warner Bros. Pictures. It received mixed reviews from critics and was a box office disappointment, earning $16 million worldwide on a budget of $11 million.