Sisters is a 2015 American comedy film directed by Jason Moore, written by Paula Pell and is the second collaboration between Tina Fey and Amy Poehler following the film Baby Mama (2008). The rest of the cast consists of Maya Rudolph, Ike Barinholtz, James Brolin, John Cena, John Leguizamo, Bobby Moynihan, and Dianne Wiest.

The film centers on adult sisters Kate (Fey), an irresponsible single mother, and Maura (Poehler), a kindhearted nurse and recent divorcee, who are summoned back to their childhood home by their parents to clean out their bedroom before the house is sold. Upset and angry that all their childhood memories will be gone, Kate convinces Maura to have one last wild house party, but things soon get out of control.

The film was released on December 18, 2015 by Universal Pictures, received mixed reviews, though most critics praised the chemistry of the lead actresses, and grossed $105 million on a production budget of $33 million.