In the Best Interest of the Children is a 1992 American made-for-television fact-based drama film starring Sarah Jessica Parker who plays a woman struggling with manic-depression while raising her five children. This leads to the children eventually being taken from her and put in foster care. The film originally premiered on NBC on Sunday, February 16, 1992.

The film was partially shot in Marengo, Iowa, roughly 30 miles west of Iowa City.