Universal Soldier: Regeneration is a 2009 American science fiction action film directed and co-edited by John Hyams, written by Victor Ostrovsky, and starring Jean-Claude Van Damme and Dolph Lundgren. It is the fifth installment in the Universal Soldier franchise and the alternative sequel to the original Universal Soldier from 1992, ignores the events from the 1999 theatrical sequel Universal Soldier: The Return and the two made for television sequels that were produced in 1998.

Mixed martial artist Andrei Arlovski stars as NGU (Next Generation UniSol), a Universal Soldier of the latest type, along with fellow fighter Mike Pyle as Capt. Kevin Burke. Tekken star Jon Foo appears as a cameo in the film as one of the four UniSols. In the United States the film was released directly to video by Sony Pictures Home Entertainment on February 2, 2010. It had a theatrical release in the Middle East and Southeast Asia and some other parts of the world. The film has received mixed reviews and theatrically grossed $844,000 with a production budget of $9 million.