Beethoven's Big Break (formerly known as Beethoven: The Reel Story and sometimes referred to as Beethoven's 6th) is a 2008 American comedy film and is the sixth installment in the Beethoven series. The film stars Jonathan Silverman, Jennifer Finnigan, Rhea Perlman, Stephen Tobolowsky, Oscar Nunez, Joey Fatone, Cesar Millan, Moises Arias, and Eddie Griffin.

It was released on DVD on December 30, 2008. The film could be considered a reboot of the series, as it completely disregards all storylines from the previous five films, though some scenes in this film include references to the original storyline.