Sisters & Brothers is a 2011 Canadian comedy-drama film written and directed by Carl Bessai. The film explores the relationships of four sets of siblings, who have not had contact for some time (in one case, never). It is the final film in Bessai's Family X trilogy exploring family relations, following Mothers & Daughters (2008) and Fathers & Sons (2010).

The film had its world premiere at the Toronto International Film Festival on September 8, 2011, followed by a limited release in Canada on March 23, 2012.