BloodRayne is a 2005 action horror film directed by Uwe Boll, from a screenplay written by Guinevere Turner. It is based on the video game franchise of the same name, from Majesco Entertainment and game developer Terminal Reality, of which it acts as a loose prequel to the first game. It is also the third video game film adaptation made by Boll, who previously made House of the Dead and Alone in the Dark. The film stars Kristanna Loken and Michelle Rodriguez alongside Michael Madsen, Matthew Davis, Will Sanderson, Billy Zane, Udo Kier, Michael Paré, Meat Loaf, Ben Kingsley and Geraldine Chaplin.

BloodRayne had its world premiere at the Austin Film Festival on October 23, 2005, and was released in the United States on January 6, 2006, and in Germany on September 14, 2006. It received negative reviews and grossed $3.7 million.

The film was followed by two sequels: BloodRayne 2: Deliverance (2007) and BloodRayne: The Third Reich (2011). Both of these sequels were also met with negative reviews.