Splice is a 2009 science fiction horror film directed by Vincenzo Natali and starring Adrien Brody, Sarah Polley, and Delphine Chanéac. The story concerns experiments in genetic engineering being done by a young scientific couple, who attempt to introduce human DNA into their work of splicing animal genes resulting in the creation of a human–animal hybrid. Guillermo del Toro, Don Murphy, and Joel Silver are credited as executive producers of this film. Theatrically released on June 4, 2010, it received generally positive reviews from critics and grossed $27.1 million against a $30 million production budget.