Tarzan's Desert Mystery is a 1943 American Tarzan film directed by Wilhelm Thiele and starring Johnny Weissmuller and Nancy Kelly.

Like its immediate predecessor, Tarzan Triumphs, the film mentions Tarzan's mate, Jane, but does not show her on screen. The explanation for her absence, as in the earlier film, is that she is still in the United Kingdom contributing to the war effort. (Maureen O'Sullivan had played Jane in the first six of Weissmuller's Tarzan films, but when the character of Jane returned after a two-picture absence, she was played by Brenda Joyce, not O'Sullivan.)

The picture's supporting players include Johnny Sheffield as "Boy", Otto Kruger, Joe Sawyer, Robert Lowery and John Dehner in an unbilled role as Prince Ameer.