The 2010 Sacrifice was a professional wrestling pay-per-view event produced by Total Nonstop Action Wrestling (TNA), which took place on May 16, 2010 at the TNA Impact! Zone in Orlando, Florida. It is the sixth event under the Sacrifice chronology and the fifth event of the 2010 TNA PPV schedule.

Ten matches were contested at the event. In the main event, Rob Van Dam defeated AJ Styles to retain the TNA World Heavyweight Championship. In other prominent matches, Sting defeated Jeff Jarrett, Jeff Hardy defeated Mr. Anderson, and in the opening contest, The Motor City Machine Guns (Alex Shelley and Chris Sabin) defeated Beer Money, Inc. (James Storm and Robert Roode) and Team 3D (Brother Devon and Brother Ray) to determine the #1 contenders to the TNA World Tag Team Championship.