Demetrius and the Gladiators is a 1954 American Technicolor/CinemaScope epic biblical drama film directed by Delmer Daves and produced by Frank Ross for 20th Century Fox. A sequel to The Robe (1953), the screenplay was written by Philip Dunne, based on characters created by Lloyd C. Douglas in The Robe.

Victor Mature stars as Demetrius, a Christian slave made to fight in the Roman arena as a gladiator, and Susan Hayward as Messalina, a reprobate who is the wife of Claudius, the uncle of the depraved emperor Caligula. The cast also features Ernest Borgnine, William Marshall, Michael Rennie, Jay Robinson as Caligula, Debra Paget, Anne Bancroft in one of her earlier roles, and Julie Newmar as a briefly seen dancing entertainer.