Doom: Annihilation is a 2019 American science fiction action film written and directed by Tony Giglio. It is a reboot based on id Software's Doom franchise and is the second live-action film after Doom (2005). The film stars Amy Manson, Dominic Mafham, Luke Allen-Gale, and Nina Bergman. In the film, marines battle demon-like creatures in a facility on Phobos, who have emerged from ancient teleportation devices known as "Gates".

Giglio pitched his idea for a new film to Universal in 2015, but was initially turned down. The success of the 2016 video game convinced Universal to proceed and commission a script from Giglio. The project was announced in April 2018, with principal photography commencing soon afterward, and ending in June, with additional photography following in early 2019. id Software publicly iterated that they were not involved with the film since they had earlier declined an invitation to participate in its production.

Doom: Annihilation was released direct-to-video on October 1, 2019 to mixed reviews and earned $78,389 (~$93,418 in 2023) in domestic video sales.