Lucy in the Sky is a 2019 American psychological drama film directed by Noah Hawley in his feature directorial debut, and co-written by Hawley, Brian C. Brown, and Elliott DiGuiseppi. The film stars Natalie Portman as astronaut Lucy Cola, loosely based on the life of real-life NASA astronaut Lisa Nowak. Alongside Portman, the cast includes Jon Hamm, Zazie Beetz, Dan Stevens, Colman Domingo, and Ellen Burstyn in supporting roles.

The plot follows Lucy Cola as she returns to Earth after a transcendent experience in space, only to find herself losing touch with reality as her life unravels. Struggling to readjust to life on Earth, Lucy embarks on a dangerous emotional and psychological journey that tests her grip on sanity.

Lucy in the Sky premiered at the 44th Toronto International Film Festival on September 11, 2019, before its theatrical release in the United States on October 4, 2019, by Fox Searchlight Pictures. The film received negative reviews from critics, who criticized its pacing, writing, and lack of character development; however, praise was directed at Portman's performance. It emerged as a commercial disaster at the box-office, grossing $325,950 worldwide against a production budget of $21.4 million.