Damon and Pythias is a 1914 American silent epic film directed by Otis Turner and starring William Worthington, Herbert Rawlinson, and Cleo Madison. It is based on the Greek legend of Damon and Pythias set during the reign of Dionysius I of Syracuse. It was an ambitious production by Universal Pictures, made at a time when feature films were rapidly replacing short films as the leading format in cinema. For much of the opening reel the cast are introduced, appearing in their modern dress rather than historical costumes.

An earlier short film adaptation of the legend was produced in 1908, also directed by Otis Turner. It was adapted again under the same title, Damon and Pythias, in 1962.