Godzilla vs. Megaguirus (ゴジラ × メガギラス G消滅作戦, Gojira tai Megagirasu: Jī Shōmetsu Sakusen, lit. Godzilla vs. Megaguirus: The G Extermination Strategy and Godzilla vs. Megaguirus: The G Annihilation Strategy) is a 2000 Japanese kaiju film directed by Masaaki Tezuka, with special effects by Kenji Suzuki. Distributed by Toho and produced under their subsidiary Toho Pictures, it is the 25th film in the Godzilla franchise and the second film in the franchise's Millennium series, as well as the 24th Godzilla film produced by Toho. The film stars Misato Tanaka, Shōsuke Tanihara, Yuriko Hoshi, Masatoh Eve, and Toshiyuki Nagashima; it also features the fictional monster characters Godzilla and Megaguirus, portrayed by Tsutomu Kitagawa and Minoru Watanabe, respectively.

Godzilla vs. Megaguirus, despite featuring the same Godzilla suit that was used in its immediate predecessor, Godzilla 2000, ignores the events of the previous installment, as well as every other entry in the franchise aside from the original 1954 film Godzilla. Godzilla vs. Megaguirus premiered at the Tokyo International Film Festival on November 3, 2000, and was released theatrically in Japan on December 16, 2000.

The film was followed by Godzilla, Mothra and King Ghidorah: Giant Monsters All-Out Attack which was released on December 15, 2001.