The Lion and the Mouse is a lost 1914 silent film drama directed by Barry O'Neil and starring Ethel Clayton. It was produced by the Lubin Manufacturing Company of Philadelphia and distributed through the General Film Company. The film was adapted from the 1905 stage production The Lion and the Mouse by English playwright Charles Klein. Unfortunately, the master negative for the screen production was destroyed in the disastrous Lubin vault fire of 1914, along with the bulk of that studio's pre-1914 film collection.