Lupin the 3rd: Blood Seal of the Eternal Mermaid is a Japanese anime television special animated by Telecom Animation Film and produced by TMS Entertainment, serving as the twenty-second television special in the Lupin the 3rd franchise, itself based on the manga series of the same name by Monkey Punch. Directed by Teiichi Takiguchi from a screenplay by Michihiro Tsuchiya, the special aired on Nippon Television on December 2, 2011 as part of the network's Kinyo Roadshow.

This was the first installment in the Lupin the 3rd franchise to feature new voice actors for Goemon Ishikawa, Fujiko Mine and Inspector Zenigata that being Daisuke Namikawa, Miyuki Sawashiro and Koichi Yamadera, all three replacing Makio Inoue, Eiko Masuyama and Gorō Naya respectively.

Discotek Media announced on August 12, 2018 that it has licensed the special in North America and was released on Blu-ray on July 30, 2019 followed by a DVD release a month later.