Life Without Soul (1915) is a lost horror film, directed by Joseph W. Smiley and written by Jesse J. Goldburg. This film is an adaptation of Mary Shelley's 1818 Gothic novel Frankenstein; or, The Modern Prometheus. The film is about a doctor who creates a soulless man. In the end, it turns out that a young man has dreamed the events of the film after falling asleep reading Shelley's novel.

This version is considered a lost film and the second film version of Frankenstein. The first version was the Edison Manufacturing Company's 12-minute short film Frankenstein (1910), written and directed by J. Searle Dawley.