Rambo: Last Blood is a 2019 American vigilante action film directed by Adrian Grünberg. The screenplay was co-written by Matthew Cirulnick and Sylvester Stallone, from a story by Dan Gordon and Stallone, and is based on the character John Rambo created by the author David Morrell for his novel First Blood. A sequel to Rambo (2008), it is the fifth installment in the Rambo film series and stars Stallone as Rambo, alongside Paz Vega, Sergio Peris-Mencheta, Adriana Barraza, Yvette Monreal, Genie Kim aka Yenah Han, Joaquín Cosío, and Óscar Jaenada. In the film, Rambo travels to Mexico to save his adopted niece, who has been kidnapped by a Mexican cartel and forced into prostitution.

Plans for a fifth film were announced on and off again since 2008, with different iterations developed and canceled. The film was finally announced in May 2018, with Grünberg attached to direct. Principal photography began in October 2018 in Bulgaria and Spain and ended in December 2018, with additional photography in May 2019. Brian Tyler returned to score the film.

Rambo: Last Blood was theatrically released on September 20, 2019, to negative reviews from critics with praise for action sequences and Stallone's performance, but criticised its script, graphic violence and accusations of racist and xenophobic attitudes towards Mexico. The film grossed $91.5 million worldwide against a production budget of $50 million and print and advertisement costs of $30 million.