Cleopatra is a 1912 American silent historical drama film starring Helen Gardner in the title role and directed by Charles L. Gaskill, based on the 1890 play written by Victorien Sardou. It was the first film to be produced by The Helen Gardner Picture Players.

Cleopatra is one of the early six-reel feature films produced in the United States. Promoted as "The most beautiful motion picture ever made", it was the first to offer a feature-length depiction of Cleopatra, although there had been a short film about Antony and Cleopatra two years earlier.