10th & Wolf is a 2006 film about the Philadelphia crime family directed by Robert Moresco. It is based on a true story of a mob war in South Philadelphia. The film stars James Marsden, Giovanni Ribisi and Brad Renfro and features appearances by Dennis Hopper, Val Kilmer, Piper Perabo, Lesley Ann Warren, Tommy Lee, 1980s Italian comedian, singer, actor and director Francesco Salvi and Brian Dennehy.

The film was billed as based on a story by "Donnie Brasco", the undercover name of FBI agent Joseph Pistone, who successfully infiltrated the Mafia, as portrayed in the movie of the same name starring Johnny Depp and Al Pacino.

While the film is set in Philadelphia, it was filmed in Pittsburgh, with scenes at Tom's Diner and Bloom Cigar Company in the South Side and Hartwood Mansion.

This film was the last film to have been released during Brad Renfro's lifetime before his death on January 15, 2008 at the age of 25 years.