Despicable Me 4 is a 2024 American animated comedy film produced by Universal Pictures and Illumination, and distributed by Universal. The sequel to Despicable Me 3 (2017), it is the fourth main installment and sixth overall entry in the Despicable Me franchise. The film was directed by Chris Renaud, co-directed by Patrick Delage, produced by Chris Meledandri and Brett Hoffman, and written by Mike White and Ken Daurio. It stars the voices of Steve Carell, Kristen Wiig, Pierre Coffin, Joey King, Miranda Cosgrove, Stephen Colbert, Sofía Vergara, Steve Coogan, Renaud, Madison Polan, Dana Gaier, Chloe Fineman, and Will Ferrell. The film sees reformed supervillain and secret agent Gru relocate his family to a safe house when his old rival Maxime Le Mal seeks revenge. Subplots deal with Gru's family adjusting to their new lives, teenage neighbor Poppy Prescott trying to follow in Gru's villainous footsteps, and a group of Gru's Minions becoming superheroes.

Development on a fourth main Despicable Me film began in September 2017. It was officially confirmed in February 2022, with Renaud, Delage, and White attached as director, co-director, and writer, respectively. Production was underway by June 2022. Most of the main voice cast was announced in January 2024, with Hoffman and Daurio revealed as co-producer and co-writer, respectively. Heitor Pereira and Pharrell Williams returned from previous installments to compose the score and write original songs and themes, respectively.

Despicable Me 4 debuted at the Jazz at Lincoln Center in New York City on June 9, 2024, and was theatrically released in the United States on July 3. Despite mixed reviews, the film continued the franchise's streak of box-office successes, grossing $971 million worldwide against a budget of $100 million, making it the fourth-highest-grossing film of 2024.