Don't Give Up on Us is a 2006 Filipino romantic comedy film directed by Joyce E. Bernal. The film was the fifth and last screen appearance of Judy Ann Santos and Piolo Pascual together (after Esperanza: The Movie, Kahit Isang Saglit, Bakit 'Di Totohanin and Till There Was You) prior to the premiering of Sa Piling Mo next month as well as the non-official entry for the 31st Metro Manila Film Festival almost 3 weeks later.Don't Give Up on Us grossed roughly ₱129 million in the Philippines. The official websites listed several international screenings but no international box-office receipts were made available by Star Cinema. It is the third Highest-Grossing Philippine-produced movie in 2006 after Sukob and Kasal, Kasali, Kasalo.

The Cinema Evaluation Board (CEB) gave Don't Give Up on Us a B rating, which made it eligible for a 65% tax rebate on its earnings in the Philippines.

The Movie and Television Review and Classification Board (MTRCB) gave Don't Give Up on Us a PG-13 rating which required parental guidance for viewers under thirteen years of age.