Guinea Pig 2: Flower of Flesh and Blood (Japanese: ギニーピッグ2 血肉の華, Hepburn: Ginī Piggu 2: Chiniku no Hana) is a 1985 Japanese splatter horror film written and directed by Hideshi Hino. The second film in the Guinea Pig film series, it is based on a manga by Hino, and stars Hiroshi Tamura and Kirara Yūgao. The film's plot concerns a man dressed as a samurai who drugs and kidnaps a woman, and proceeds to take her to his home, where he dismembers her and adds her body parts to a collection.

Guinea Pig 2 garnered controversy both in Japan and in the United States. The film was reportedly withdrawn from the home video market, and was suspected to have been an influence on Tsutomu Miyazaki, a serial killer who abducted and murdered four young girls. Despite this, upon release, Guinea Pig 2 positioned itself on the list of top ten video releases in Japan for two months straight. American actor Charlie Sheen is said to have watched the film and became convinced that it genuinely depicted the killing and dismemberment of an actual woman, prompting him to contact authorities. Investigations were dropped after the special effects used to simulate the violence depicted in the film were able to be demonstrated.

The film is also known by a number of other titles which vary slightly, including Guinea Pig 2: Flowers of Flesh and Blood.