Miracle at St. Anna is a 2008 epic war film directed by Spike Lee and written by James McBride, based on McBride's 2003 novel. The film stars Derek Luke, Michael Ealy, Laz Alonso, Omar Benson Miller, Pierfrancesco Favino and Valentina Cervi, with John Turturro, Joseph Gordon Levitt, John Leguizamo, D.B. Sweeney and Kerry Washington in supporting roles. Set primarily in Italy during the Italian campaign of World War II, the film tells the story of four Buffalo Soldiers of the 92nd Infantry Division who seek refuge in a small Tuscan village, where they form a bond with the residents. The story is presented as a flashback, as one survivor, Hector Negron (Alonso), reflects upon his experiences in a frame story set in 1980s New York. Several real-life events that occurred during the war, such as the Sant'Anna di Stazzema massacre, are re-enacted, placing Miracle at St. Anna within the genre of historical fiction.

The film is a co-production of the United States and Italy. Lee first learned of the novel in 2004 and approached McBride with the idea of a film adaptation. In Europe, the film's development attracted the attention of Italian film producers Roberto Cicutto and Luigi Musini, who helped finance the $45 million production. A majority of the film was shot in Italy, on several locations affected by World War II. Other filming locations included New York, Louisiana and the Bahamas. Frequent Lee collaborator Terence Blanchard composed the score, and the visual effects were created by Industrial Light & Magic.

Miracle at St. Anna premiered at the 2008 Toronto International Film Festival before it was released on September 26, 2008. It was met with mostly negative reviews from critics and drew controversy in Italy over historical inaccuracies. During its theatrical run, Miracle at St. Anna was a box office bomb, grossing only $9.3 million worldwide.