House of Numbers: Anatomy of an Epidemic is a 2009 film directed, produced, and hosted by Brent Leung and described by him as an objective examination of the idea that HIV causes AIDS. The film argues that human immunodeficiency virus (HIV) is harmless and does not cause acquired immune deficiency syndrome (AIDS), a position known as AIDS denialism. The film's claims of impartiality have been widely rejected by scientists, and the film's claims about HIV and AIDS have been dismissed as pseudoscience and conspiracy theory masquerading as even-handed examination.

A group of scientists interviewed for the film later complained that their comments had been misrepresented and taken out of context, and that the film promotes pseudoscience. The film also interviews Christine Maggiore, a prominent AIDS denialist who later died following AIDS-related conditions.