Wake Up Little Susie is a 1988 Filipino comedy film directed by Luciano B. Carlos and starring the comedy trio of Tito Sotto, Vic Sotto and Joey de Leon alongside child actress Ice Seguerra as the titular character. The film also stars Lotlot de Leon, Ramon Christopher, Kristina Paner, Cris Villanueva, Manilyn Reynes and Janno Gibbs. Produced by Regal Films, it was released on April 27, 1988.

Critic Lav Diaz gave the film a mixed review, criticizing its unoriginality and the unnecessary addition of musical scenes involving love teams while commending the hilarity of Tito, Vic and Joey.