Panic is a 2000 American crime drama film written and directed by Henry Bromell and starring William H. Macy in the lead role, alongside Neve Campbell, Tracey Ullman, John Ritter, Miguel Sandoval, and Donald Sutherland. The film centers on Alex (Macy), a hitman who suffers a midlife crisis amidst the number of struggles he and his family face. Determined to quit contract killing, he seeks treatment from therapist Dr. John Parks (Ritter) and enters an affair with a younger woman, Sarah Cassidy (Campbell).

Panic premiered at the 2000 Sundance Film Festival, and was later given a limited release in theaters in December of that year. The film received universal acclaim from major film critics, who in particular praised the performances of the acting ensemble.