12 Hour Shift is a 2020 American black comedy horror film written and directed by Brea Grant and starring Angela Bettis, Kit Williamson, and David Arquette. Bettis plays Mandy, a drug-addicted nurse involved in a black market organ-trading scheme in 1999. Arquette was one of the film's producers, alongside his wife Christina Arquette, and Jordan Wayne Long, Tara Perry, and Matt Glass. The film also features music composed by Glass.

12 Hour Shift was scheduled to have its world premiere at the Tribeca Film Festival in April 2020 prior to the festival being postponed due to the COVID-19 pandemic. Distribution rights were acquired by Magnet Releasing in June 2020, and it premiered at the Fantasia International Film Festival in September 2020. The film earned positive reviews from critics, who praised the cast—especially Bettis and Farnsworth—and humor.