The 2011 Night of Champions was the fifth annual Night of Champions professional wrestling pay-per-view (PPV) event produced by WWE. It took place on September 18, 2011, at the First Niagara Center in Buffalo, New York. It was WWE's first PPV event to be held following the dissolution of the original brand extension. The concept of the show was that every championship in the company at the time was defended.

Eight matches took place at the event, seven of which were broadcast live on pay-per-view. The event featured multiple main events, with Triple H defeating CM Punk in a No Disqualification match with a stipulation where had Triple H lost, he would have no longer been Chief Operating Officer of WWE, John Cena defeating Alberto Del Rio for the WWE Championship, and Mark Henry defeating Randy Orton for the World Heavyweight Championship.

The event garnered 161,000 buys, down from 165,000 buys the previous year.