One Mysterious Night is a 1944 crime film, the seventh in a Columbia Pictures series of fourteen starring Chester Morris as reformed crook Boston Blackie. It was preceded by The Chance of a Lifetime and followed by Boston Blackie Booked on Suspicion. Blackie is called upon to recover a stolen diamond.

The film is noteworthy as the directorial debut of Budd Boetticher, though he is credited under his real name, Oscar Boetticher, Jr. He had been working at Columbia as an assistant director on such films as The Desperadoes and Cover Girl. He had been called in to help complete films but called this his "first real picture".

He helmed four more B-pictures before leaving the studio in 1945.