The 2020 NXT TakeOver: In Your House was the 29th NXT TakeOver and 28th In Your House professional wrestling event produced by WWE, and the inaugural In Your House held for the promotion's NXT brand division. The event was streamed exclusively on the WWE Network on June 7, 2020. While the majority of the event aired live from Full Sail University in Winter Park, Florida, the Backlot Brawl match was pre-recorded on May 28 in the parking lot of Full Sail.

The event marked the 25th anniversary of the first In Your House pay-per-view event. It was also the first In Your House branded event since February 1999, thus being the first In Your House to air on the WWE Network. It was also the first TakeOver event to be held at Full Sail University since TakeOver: The End in June 2016. That event had been promoted as the final TakeOver to be held at Full Sail; however, the COVID-19 pandemic necessitated all of NXT's events to be held here behind closed doors until NXT's events were relocated to the WWE Performance Center in Orlando in October. As a result, it was the first TakeOver to be held during the pandemic.

Six matches were contested at the event. In the main event, Io Shirai defeated defending champion Charlotte Flair and Rhea Ripley in a triple threat match to win the NXT Women's Championship. On the undercard, Karrion Kross defeated Tommaso Ciampa by technical submission, Keith Lee defeated Johnny Gargano to retain the NXT North American Championship, and Adam Cole defeated Velveteen Dream in a Last Chance Backlot Brawl to retain the NXT Championship, which was a cinematic match.