The 2010 TLC: Tables, Ladders & Chairs was the second annual TLC: Tables, Ladders & Chairs professional wrestling pay-per-view (PPV) event produced by World Wrestling Entertainment (WWE). It was held for wrestlers from the promotion's Raw and SmackDown brand divisions. The event took place on December 19, 2010, at the Toyota Center in Houston, Texas. It was the last TLC held under the first brand split, which ended in August 2011, but was reinstated in July 2016.

Seven matches were contested at the event. In the main event, John Cena defeated Wade Barrett in a Chairs match. Other prominent matches included The Miz retaining the WWE Championship against Randy Orton in a Tables match, Edge defeated defending champion Kane, Rey Mysterio and Alberto Del Rio to win the World Heavyweight Championship in a Tables, Ladders and Chairs match, and in the opening bout, Dolph Ziggler retained as the Intercontinental Champion against Jack Swagger and Kofi Kingston in a Triple Threat Ladder match.