The 2006 Vengeance was the sixth annual Vengeance professional wrestling pay-per-view (PPV) event produced by World Wrestling Entertainment (WWE). It was held exclusively for wrestlers from the promotion's Raw brand division. The event took place on June 25, 2006, at the Charlotte Bobcats Arena in Charlotte, North Carolina. It was the final brand-exclusive Vengeance event until 2021.

Eight professional wrestling matches were featured on the event's card. The card featured eight televised matches, including two main events which resulted in Rob Van Dam defeating Edge to retain the WWE Championship and D-Generation X (DX) (Triple H and Shawn Michaels) defeating Spirit Squad (Kenny, Johnny, Mitch, Nicky, and Mikey) in a 5-on-2 handicap match. One bout was featured on the undercard, in which John Cena defeated Sabu in an Extreme Rules lumberjack match, which featured superstars from the Raw and ECW brands at ringside.

Vengeance grossed over US$400,000 in ticket sales from an attendance of 6,800 and received 320,000 pay-per-view buys, which helped WWE increase its pay-per-view revenue by $21.6 million compared to the previous year. When the event was released on DVD, it reached the number one position on Billboard's DVD Sales Chart. The professional wrestling section of the Canadian Online Explorer website rated the entire event a 6.5 out 10 stars, higher than the 2005 event rating of 6 out 10.