The 2006 Backlash was the eighth Backlash professional wrestling pay-per-view (PPV) event produced by World Wrestling Entertainment (WWE). It was held exclusively for wrestlers from the promotion's Raw brand division. The event took place on April 30, 2006, at the Rupp Arena in Lexington, Kentucky. It was the last Backlash event to be Raw-exclusive as following WrestleMania 23 the following year, brand-exclusive PPVs were discontinued. The concept of the pay-per-view was based around the backlash from WrestleMania 22.

Seven professional wrestling matches were scheduled on the event's card, which saw three main matches. The first of these main events was a triple threat match for the WWE Championship, which saw John Cena defeat challengers Triple H and Edge to retain his title. The second main event was Shawn Michaels and "God" versus Vince and Shane McMahon in a No Holds Barred match, which was won by the McMahons. The third main event was a "Title vs. Briefcase match" that pitted Mr. Money in the Bank Rob Van Dam against Intercontinental Champion Shelton Benjamin, with both men defending their respective titles. Van Dam defeated Benjamin, thus retaining his Money in the Bank briefcase and winning the Intercontinental Championship.

The event received 273,000 pay-per-view buys, which was more than the previous year's event received. This contributed to WWE's pay-per-view revenue increasing by $4.3 million from the previous year. When the event was released on DVD, it peaked at second on Billboard's DVD sales chart for recreational sports.