Live from Madison Square Garden, also called Live from MSG: Lesnar vs. Big Show, was a professional wrestling live event produced by WWE. It was livestreamed exclusively on the WWE Network. The event took place on October 3, 2015, and was broadcast from Madison Square Garden in New York City, New York. It was hailed as part of Brock Lesnar's "Go To Hell Tour" as well as his return to Madison Square Garden in his first match in the arena since his original departure from the company in 2004. The event also marked the 25th anniversary of Chris Jericho's debut in professional wrestling.

Nine matches were contested at the event, as well as two dark matches. In the main event, John Cena defeated Seth Rollins in a steel cage match to retain the WWE United States Championship. In another prominent match for which the event was promoted around, Brock Lesnar defeated Big Show. Also on the undercard, Kevin Owens defeated Chris Jericho to retain the WWE Intercontinental Championship and The Dudley Boyz (Bubba Ray Dudley and D-Von Dudley) defeated WWE Tag Team Champions The New Day (Big E and Kofi Kingston) by disqualification, thus The New Day kept their title.