The 2016 No Mercy was the 12th No Mercy professional wrestling pay-per-view (PPV) and livestreaming event produced by WWE. It was held exclusively for wrestlers from the promotion's SmackDown brand division. The event took place on October 9, 2016, at the Golden 1 Center in Sacramento, California. It was the first No Mercy held since 2008 and it was also the first SmackDown-exclusive No Mercy since 2006. This also made it the first No Mercy to livestream on WWE's online streaming service, the WWE Network, which launched in 2014. Unlike the majority of WWE's PPVs, No Mercy 2016 was not released on DVD or Blu-Ray.

Eight matches were contested at the event, including one on the Kickoff pre-show. In the advertised main event, AJ Styles defeated Dean Ambrose and John Cena in a triple threat match to retain the WWE World Championship; this was the opening bout. The advertised main event was originally scheduled to close the event, but was changed the day of the event due to the second United States presidential debate airing at the same time that the match would have occurred. Due to this change, the final match saw Bray Wyatt face Randy Orton, which Wyatt won. In another prominent match, Dolph Ziggler defeated The Miz to win the Intercontinental Championship in a title vs. career match.