Murder in Space is also the title of a 1955 science fiction novel by David V. Reed and a 2007 mystery novel by Sydney J. Bounds.

Murder in Space is a 1985 science fiction murder mystery television movie set in the near future. The crew of an international space mission are on the return leg from Mars to Earth when an explosion occurs on the craft Conestoga, shortly after a series of murders starts. The crew of the returning craft are forbidden to return until the murderer is caught.

On its initial worldwide premiere, the film was shown without the ending and a competition was set for the viewers to solve the mystery of who the murderer or murderers were. The conclusion of the film was shown several days later, with the contestants eliminated one by one until the winner correctly identified the killer or killers. The final 15 minutes of the film was shown at a later date when the mystery was solved with only two countries provided winners with the correct answer.